Glossary
Addiction: A chronic, relapsing disease, characterized
by compulsive drug seeking and use and by neurochemical and molecular
changes in the brain.
Barbiturate: A type of central nervous system (CNS) depressant
often prescribed to promote sleep.
Benzodiazepine: A type of CNS depressant prescribed to
relieve anxiety; among the most widely prescribed medications,
including Valium and Librium.
Buprenorphine: A new medication awaiting FDA approval
for treatment of opioid addiction. It blocks the effects of opioids
on the brain.
Central nervous system (CNS): The brain and spinal cord.
CNS depressants: A class of drugs that slow CNS function,
some of which are used to treat anxiety and sleeping disorders;
includes barbiturates and benzodiazepines.
Detoxification: A process that allows the body to rid
itself of a drug while at the same time managing the individual's
symptoms of withdrawal; often the first step in a drug treatment
program.
Dopamine: A neurotransmitter present in regions of the
brain that regulate movement, emotion, motivation, and feelings
of pleasure.
LAAM (levo-alpha-acetyl-methadol): An approved medication
for the treatment of opioid addiction, taken 3 to 4 times a week.
Methadone: A long-acting synthetic medication that is
effective in treating opioid addiction.
Narcolepsy: A disorder characterized by uncontrollable
episodes of deep sleep.
Norepinephrine: A neurotransmitter present in some areas
of the brain and the adrenal glands; decreases smooth muscle contraction
and increases heart rate; often released in response to low blood
pressure or stress.
Opioids: Controlled drugs or narcotics most often prescribed
for the management of pain; natural or synthetic chemicals based
on opium's active component - morphine - that work by mimicking
the actions of pain-relieving chemicals produced in the body.
Opiophobia: A health care provider's unfounded fear that
patients will become physically dependent upon or addicted to
opioids even when using them appropriately; can lead to the underprescribing
of opioids for pain management.
Physical dependence: An adaptive physiological state that
can occur with regular drug use and results in withdrawal when
drug use is discontinued.
Polydrug abuse: The abuse of two or more drugs at the
same time, such as CNS depressant abuse accompanied by abuse of
alcohol.
Prescription drug abuse: The intentional misuse of a medication
outside of the normally accepted standards of its use.
Prescription drug misuse: Taking a medication in a manner
other than that prescribed or for a different condition than that
for which the medication is prescribed.
Psychotherapeutics: Drugs that have an effect on the function
of the brain and that often are used to treat psychiatric disorders;
can include opioids, CNS depressants, and stimulants.
Respiratory depression: Depression of respiration (breathing)
that results in the reduced availability of oxygen to vital organs.
Stimulants: Drugs that enhance the activity of the brain
and lead to increased heart rate, blood pressure, and respiration;
used to treat only a few disorders, such as narcolepsy and attention-deficit
hyperactivity disorder.
Tolerance: A condition in which higher doses of a drug
are required to produce the same effect as experienced initially.
Tranquilizers: Drugs prescribed to promote sleep or reduce
anxiety; this National Household Survey on Drug Abuse classification
includes benzodiazepines, barbiturates, and other types of CNS
depressants.
Withdrawal: A variety of symptoms that occur after chronic
use of some drugs is reduced or stopped.
References
American Psychiatric Association. Benzodiazepine Dependence,
Toxicity, and Abuse: A Task Force Report of the American Psychiatric
Association. Washington, DC: American Psychiatric Association,
1990.
Center for Substance Abuse Treatment (CSAT). Detoxification
from Alcohol and Other Drugs, Treatment Improvement Protocol
(TIP) #19. Department of Health and Human Services (DHHS) Pub.
No. BKD172. Substance Abuse and Mental Health Services Administration
(SAMHSA),1995.
CSAT. Substance Abuse Among Older Adults, TIP #26. DHHS
Pub. No. BKD250. SAMHSA, 1997.
CSAT. Substance Abuse Among Older Adults (TIP #26): Physicians
Guide. DHHS Pub. No. (SMA) 00-3394. SAMHSA, 2000.
Hardman, J.G.; Limbird, L.E.; Molinoff, P.B.; Ruddon, R.W.; and
Gilman, A.G., eds. Goodman & Gilman's The Pharmacological
Basis of Therapeutics 9th Ed. New York: McGraw-Hill, 1996.
Isaacson, J.H. Preventing Prescription Drug Abuse. Cleveland
Clinic Journal of Medicine 67(7): 473-475, 2000.
Johnston, L.D.; O'Malley, P.M.; and Bachman, J.G. Monitoring
the Future: National Survey Results on Drug Use, 1975-1999,
2 Vols. NIH Pub. No. 00-4803. National Institute on Drug Abuse
(NIDA), NIH, DHHS, 2000.
Joransson, D.E.; Ryan, K.M.; Gilson, A.M.; and Dahl, J.L. Trends
in medical use and abuse of opioid analgesics. Journal of the
American Medical Association 283(13):1710-1714, 2000.
Longo, L.P., and Johnson, B. Addiction: Part I. Benzodiazepines-side
effects, abuse risk, and alternatives. American Family Physician
61:2121-2131, 2000.
Longo, L.P.; Parran, T.; Johnson, B.; and Kinsey, W. Addiction:
Part II. Identification and management of the drug-seeking patient.
American Family Physician 61:2401-2408, 2000.
National Center on Addiction and Substance Abuse at Columbia
University (CASA). Missed Opportunity: National Survey of Primary
Care Physicians and Patients on Substance Abuse. New York:
CASA, 2000.
NIDA. NIDA Infofax #13553, Pain Medications, 1999.
NIDA. Principles of Drug Addiction Treatment: A Research-Based
Guide. NIH Pub. No. 99-4180. NIDA, NIH, DHHS, 1999.
NIDA NOTES. Research eases concerns about use of opioids to relieve
pain, NIDA NOTES 15(1):12-13, 2000.
Office of Applied Studies. Substance Use Among Women in the
United States. DHHS Pub. No. (SMA) 97-3162. SAMHSA, 1997.
Office of Applied Studies. Summary of Findings from the National
Household Survey on Drug Abuse. DHHS Pub. No. (SMA) 00-3466.
SAMHSA, 2000.
Office of Applied Studies. Year-End 1999 Emergency Department
Data from the Drug Abuse Warning Network. DHHS Pub. No.(SMA)
00-3462. SAMHSA, 2000.
Patterson, T.L., and Jeste, D.V. The potential impact of the
baby-boom generation on substance abuse among elderly persons.
Psychiatric Services 50:1184-1188, 1999.
Phillips, D.M. JCAHO pain management standards are unveiled.
Journal of the American Medical Association 284(4):428-429,
2000.
Simoni-Wastila, L. The use of abusable prescription drugs: The
role of gender. Journal of Women's Health and Gender-based
Medicine 9(3):289-297, 2000.
Snyder, S.H. Drugs and the Brain. New York: Scientific
American Library, 1996.
Wilford, B.B; Finch, J.; Czechowicz, D.J.; and Warren D. An overview
of prescription drug misuse and abuse: Defining the problem and
seeking solutions. Journal of Law, Medicine & Ethics
22(3):197-203, 1994.